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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and <t>Bonferroni</t> post hoc test ( C ).
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Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and Bonferroni post hoc test ( C ).

Journal: Cells

Article Title: Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn’s Disease

doi: 10.3390/cells10061349

Figure Lengend Snippet: Active CD is associated with mitochondrial ultrastructural abnormalities in enterocytes and goblet cells. ( A , B ) Representative TEM image of enterocytes ( A ) and goblet cells ( B ). Yellow star denotes normal mitochondria, red star mitochondria with ultrastructural abnormality. Scale bars: 2 μm, boxed pullout: 1 μm. ( C ) Quantitation of mitochondria with ultrastructural abnormalities. Results are presented as individual data points ± SEM of 30 inactive and 19 active CD patients. **** p < 0.001 by one-way ANOVA and Bonferroni post hoc test ( C ).

Article Snippet: Multiple comparisons were conducted with either one-way or two-way ANOVA followed by a Bonferroni post hoc test (GraphPad Prism 8.4.2, San Diego, CA, USA).

Techniques: Quantitation Assay